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The Science of Living Well
Products > Vitamin K2 (Super K) April 8, 2020
Vitamin K2 (Super K)
Manufactured by Life Extension
Vitamin K supplement with K1 and two forms of K2

Life Extension's Super K combines vitamin K1 with two forms of vitamin K2 in a once-daily vitamin K supplement to help support bone & heart health.

Supplement Information COUNT ADD 
Vitamin K2 (Super K) 90 softgel $30.00
Clinically, a lower intake of vitamin K has translated into a greater risk for myocardial infarction and stroke, plaque instability, and most recently, diabetes.5,6 A greater intake of vitamin K, particularly K2, has been associated with lower all-cause mortality, coronary heart disease, aortic calcification, as well as cancer incidence and fatality.7,8 Higher intake of MK-7, which has the longest half-life and the most extra-hepatic distribution, has been associated with lower risk of fracture and greater BMD.9,10,11,12,13

  • Provides 100 mcg per serving of vitamin K2 as Menaquinone-7 (MK-7)
  • MK-7 has the greatest half-life of all forms of vitamin K, as well as the best extra-hepatic distribution
  • Vitamin K2, particularly MK-7, allows for much lower dosing with significant clinical benefit
1 softgel per day or as directed by a health care practitioner.

Supplement Facts
Serving Size, 1
Amount Per capsule % Daily Value
Vitamin C (as Ascorbyl palmitate) 10 mg. 11%
Vitamin K activity from: 2600 mcg. 2167%
Vitamin K1 (as phytonadione) 1500 mcg
Vitamin K2 (as menaquinone-4) 1000 mcg.
Vitamin K2 (as all-trans menaquinone-7) 100 mcg. *   
* Daily value not established
Other Ingredients: extra virgin olive oil, gelatin, glycerin, beeswax, purified water, carob color, microcrystalline cellulose, maltodextrin
More information about Vitamin K2 (Super K) Contraindications: Consult a health care professional prior to use if you are taking blood thinners. Vitamin K supplementation should be used with caution in patients with liver disease, or undergoing hemodialysis. Keep out of reach of children.

References

1. Vos M, et al. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 2012 Jun 8;336(6086):1306-10.

2. Vermeer C. Vitamin K: the effect on health beyond coagulation - an overview. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.5329.

3. Chatrou ML, et al. Role of vitamin K-dependent proteins in the arterial vessel wall. Hamostaseologie. 2011 Nov;31(4):251-7.

4. McCann JC, et al. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr. 2009 Oct;90(4):889-907.

5. Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Oct 3. [Epub ahead of print].

6. Schurgers LJ, et al. Vitamin k-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PLoS One. 2012;7(8):e43229.

7. Geleijnse JM, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J. Nutr. 2004. 134:3100�5.

8. Nimptsch K, et al. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2010 May;91(5):1348-58.

9. Schurgers LJ, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83.

10. Katsuyama H, et al. Usual dietary intake of fermented soybeans (natto) is associated with bone mineral density in premenopausal women. J. Nutr. Sci. Vitaminol. (Tokyo) 2002. 48:207�15.

11. Ikeda Y, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis Study (JPOS). J. Nutr. 2006. 136:1323�28.

12. Fujita Y, et al. Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Osteoporos Int. 2011 Mar 11. [Epub ahead of print].

13. Cockayne S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2006 Jun 26;166(12):1256-61.

14. Ford SK, et al. Vitamin K supplementation to decrease variability of International Normalized Ratio in patients on vitamin K antagonists: a literature review. Curr Opin Hematol. 2008 Sep;15(5):504-8.

15. Weijs B, et al. Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients. Eur Heart J. 2011 Oct;32(20):2555-62.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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